Archives of Acoustics, 43, 1, pp. 137–146, 2018

The Influence of a Single Therapeutic Dose of Methadone on Selected Auditory Functions in Patients Addicted to Opioids and Undergoing Substitution Therapy – a Preliminary Study

Adam Mickiewicz University

Andrzej WICHER
Adam Mickiewicz University

Aleksander SĘK
Adam Mickiewicz University

Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Nicolaus Copernicus University Collegium Medicum Non-Public Health Care Center Sue Ryder Home Medseven – Outpatient Addiction Treatment Institute of Philosophy, Kazimierz Wielki University

The main purpose of this research was to determine the influence of a therapeutic dose of an opioid drug (methadone) on selected auditory functions in patients addicted to opioids (recognition ICD-10; F11) and undergoing substitution therapy. Various hearing tests were used in this research – pure tone audiometry, impedance audiometry, otoacoustic emission measurement, and a speech in noise test – in two sessions, before and after methadone intake. It was found that methadone causes an improvement in speech intelligibility when speech is presented in speech-like noise, and slightly decreases hearing thresholds [dB HL]. Methadone consumption has no significant impact on distortion product otoacoustic emissions levels (DPOAE). In summary, a prescribed methadone dose does not worsen the hearing of opioid-dependent subjects.
Keywords: methadone; opioids; speech intelligibility; otoacoustic emissions; hearing threshold
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Copyright © Polish Academy of Sciences & Institute of Fundamental Technological Research (IPPT PAN).


Al-Mana D., Ceranic B., Djahanbakhch O.,Luxon L.M. (2008), Hormones and the auditory system: a review of physiology and pathophysiology, Neuroscience, 153, 881–900.

Antonopoulos S., Balatsouras D.G., Kanakaki S., Dona A., Spiliopoulou C.,Giannoulis G. (2012), Bilateral sudden sensorineural hearing loss caused by alcohol abuse and heroin sniffing, Auris Nasus Larynx, 39, 305–309.

Benyamin R., Trescot A.M., Datta S., Buenaventura R., Adlaka R., Sehgal N., Glaser S.E., Vallejo R. (2008), Opioid complications and side effects, Pain Physician, S105–S120.

Christenson B.J.,Marjala A.R. (2010), Two cases of sudden sensorineural hearing loss after methadone overdose, Ann Pharmacother, 44, 207–210.

Cianfrone G., Pentangelo D., Cianfrone F., Mazzei F., Turchetta R., Orlando M.P., Altissimi G. (2011), Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide, European Review for Medical and Pharmacological Sciences, 15, 601–636.

Corbett A.D., Henderson G., McKnight A.T., Paterson S.J. (2006), 75 years of opioid research: the exciting but vain quest for the Holy Grail, British Journal of Pharmacology, 147 Suppl 1, S153–162.

Feit J., Kunc M., Walecki P., Gorzelańczyk E.J. (2014), Oculomotor disturbances in HIV-positive individuals treated with methadone, Postepy Higieny i Medycyny Doświadczalnej (Online), 68, 1415–1420.

Feit J., Litmanowski P., Gorzelańczyk E.J. (2010), The contribution of opioid receptors to opioid addiction [in Polish: Udział receptorów opioidowych w uzależnieniu od opioidów], Episteme, 11, 227–236.

Fowler V.G., King J.L. (2008), Sudden bilateral sensorineural hearing loss following speedballing, Journal of the American Academy of Audiology, 19, 461–464.

Gierek T., Slaska-Kaspera A. (2007), The stapedius muscle – the present opinions about anatomy and physiology, Otolaryngolia Polska, 61, 29–32.

Gorzelańczyk E.J. (2011), Functional anatomy, physiology and clinical aspects of Basal Ganglia, in: Neuroimaging for Clinicians – Combining Research and Practice, J.F.P. Peres (Ed.)(InTech), pp. 89–106.

Gorzelańczyk E.J., Fareed A., Walecki P., Feit J., Kunc M. (2014), Risk behavior in opioid-dependent individuals after the administration of a therapeutic dose of methadone, American Journal on Addictions, 23, 608–612.

Gorzelańczyk E.J., Walecki P., Feit J., Kunc M., Fareed A. (2016), Improvement of Saccadic Functions After Dosing with Methadone in Opioid Addicted Individuals, Journal of Addictive Diseases, 35, 52–57.

Harris P.K., Hutchinson K. M., Moravec J. (2005), The use of tympanometry and pneumatic otoscopy for predicting middle ear disease, American Journal of Audiology, 14, 3–13.

International Narcotics ControlBoard (2013), Yellow list – List of narcotic drugs under international control, Vienna.

Ishiyama A., Ishiyama G., Baloh R.W., Evans C.J. (2001), Heroin-induced reversible profound deafness and vestibular dysfunction, Addiction, 96, 1363–1364.

Kalat J.W. (2011), Biological basis of psychology [in Polish: Biologiczne podstawy psychologii], Wydawnictwo Naukowe PWN, Warszawa.

Laskowska I., Gorzelańczyk E.J. (2009), The role of the basal nucleus in cognitive function regulating [in Polish: Rola jąder podstawy w regulacji funkcji poznawczych], Neuropsychiatria i Neuropsychologia, 4, 26–35.

Lopez I.A., Ishiyama A., Ishiyama G. (2012), Sudden sensorineural hearing loss due to drug abuse, Seminars in Hearing, 33, 251–260.

Moore B.C.J. (1999), Introduction to the psychology of hearing [in Polish: Wprowadzenie do psychologii słyszenia, Wydawnictwo Naukowe PWN, Warszawa–Poznań.

Nair E.L., Cienkowski K.M., Michaelides E. (2010), The impact of sudden hearing loss secondary to heroin overdose on fitting outcomes, American Journal of Audiology, 19, 86–90.

NCBI (2005), Methadone (PubChem Compound Database),

Nguyen K.D., Lopez I.A., Ishiyama G., Ishiyama A. (2014a), Review of opioid-associated hearing loss and possible mechanism of opioid-mediated endothelin-1-dependent cochlear vasoconstriction, Journal of Otology and Rhinology, 3.

Nguyen K.D., Mowlds D., Lopez I.A., Hosokawa S., Ishiyama A., Ishiyama G. (2014b), Mu-opioid receptor (MOR) expression in the human spiral ganglia, Brain Research, 1590, 10–19.

Ozimek E., Kutzner D., Sek A.,Wicher A. (2009), Polish sentence tests for measuring the intelligibility of speech in interfering noise, International Journal of Audiology, 48, 433–443.

Ozimek E., Kutzner D., Sęk A.,Wicher A. (2008), New tests for speech intelligibility measurement in noise for Polish language: sentence test and digital triplet test [in Polish: Nowe testy do pomiarów zrozumiałości mowy w szumie dla języka polskiego: test zdaniowy oraz test trypletów cyfrowych], Biuletyn Polskiego Stowarzyszenia Protetyków Słuchu, Zarząd Polskiego Stowarzyszenia Protetyków Słuchu, Poznań, pp. 16–21.

Pankowska M., Hojan-Jezierska D., Skrodzka E., Szymiec E., Kubisz L., Świdzinski T.,Wicher A. (2011), Effect of ELF magnetic stimulation on distortion product of otoacoustic emission in tinnitus patients, Acta Physica Polonica A, 119, 1035–1039.

Schrock A., Jakob M., Wirz S., Bootz F. (2008), Sudden sensorineural hearing loss after heroin injection, European Archives of Oto-Rhino-Laryngology, 265, 603–606.

Shaw K.A., Babu K.M., Hack J.B. (2011), Methadone, another cause of opioid-associated hearing loss: a case report, Journal of Emergency Medicine, 41, 635–639.

Śliwińska-Kowalska M. (2005), Clinical audiology [in Polish: Audiologia kliniczna], Mediton, Łódź.

van Gaalen F.A., Compier E.A., Fogteloo A.J. (2009), Sudden hearing loss after a methadone overdose, European Archives of Oto-Rhino-Laryngology, 266, 773–774.

Victor W.R., Vieweg M.D., William F., Lipps C., Pharm D., Fernandez A. (2005), Opioids and methadone equivalents for clinicians, Primary Care Companion Journal of Clinical Psychiatry, 7, 86–88.

Vorasubin N., Calzada A.P., Ishiyama A. (2013), Methadone-induced bilateral severe sensorineural hearing loss, American Journal of Otolaryngology, 34, 735–738.

WHO/UNODC/UNAIDS (2004), Substitution maintenance therapy in the management of opioid dependence and HIV/AIDS prevention: position paper, World Health Organization, United Nations Office on Drugs and Crime, UNAIDS, Edited by World Health Organization, United Nations Office on Drugs and Crime, and UNAIDS (WHO).

Wicher A. (2012), The effect of amplitude modulated contralateral signals on distortion product otoacoustic emissions, Acta Physica Polonica A, 121, A78–A81.

Wicher A. (2013), The effect of contralateral signal on distortion product otoacoustic emissions and psychophysical tuning curves at 1 and 2 kHz, Acta Physica Polonica A, 123, 1001–1006.

Wicher A. (2014), The influence of contralateral stimulation on distortion product otoacoustic emissions (DPOAEs) and the masking effect [in Polish: Ocena wpływu stymulacji kontralateralnej na otoemisje akustyczne produktów zniekształceń nieliniowych (DPOAE) i efekt maskowania], Wydawnictwo Naukowe UAM, Poznań.

Wicher A., Moore B.C. (2014), Effect of broadband and narrowband contralateral noise on psychophysical tuning curves and otoacoustic emissions, Journal of the Acoustical Society of America, 135, 2931–2941.

Yates S.J. (2009), An evaluation of the cognitive functioning of individuals on methadone maintenance treatment and its relation to treatment adherence, University of Waikato, Waikato.

DOI: 10.24425/118089