Archives of Acoustics, 40, 4, pp. 569–574, 2015

Ultrasonic Investigations of Inclusion Complexation of α-Cyclodextrin by DMSO in Pseudo-Binary Aqueous System

Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan, Poland

Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan, Poland

Institute of Acoustics, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan, Poland

Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan, Poland

The paper reports the study of the complexation processes in aqueous solution of α-CD and DMSO. Cyclodextrins (CDs) (sometimes called cycloamyloses) are cyclic oligosaccharides formed by glucose units interconnected by α-(1,4) linkages; α-CD is one of three the most common CDs. It consists of six glucopyranose units. The speed of ultrasonic waves has been measured by the resonance method on ResoscanTM System apparatus. Some collateral data, such as density and heat capacity of the system, have also been measured. On the basis of the experimental data the excess adiabatic compressibility was determined. The extremes of the excess adiabatic compressibility function for different mixture compositions allowed us to establish the composition of molecular complexes formed in the solution. The obtained results suggest the formation of the α-CD with DMSO inclusion complexes with chemical stoichiometric ratio value of 1:1.
Keywords: ultrasonic speed; compressibility; complexation.
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Copyright © Polish Academy of Sciences & Institute of Fundamental Technological Research (IPPT PAN).


Douhéret G., Davis M.I., Reis J.C.R. (2005), Letter to the Editor – Fluid Phase Equilibria, 231, 246–249.

Dsouza V.T., Lipkowitz K.B. (1998), Cyclodextrins: Introduction, Chem. Rev., 98, 5, 1741–1742.

Eggers F., Kaatze U. (1996), Broad-band ultrasonic measurement techniques for liquids, Meas. Sci. Technol., 7, 1, 1–9.

Immel S., Lichtenthaler F.W. (1995), A New Look at the Hydrophobic Characteristics of Cyclodextrins, Cyclomannins, Cyclogalactins, Cyclofructins, and of Starch, 8th European Carbohydrate Symposium – EUROCARB VIII, Abstract B38.

Kaatze U., Pottel R., Schafer M. (1989), Dielectric spectrum of dimethyl

sulfoxide/water mixtures as a function of composition, J. Phys. Chem., 93, 14, 5623–5627.

Kaatze U., Brai M., Scholle F.D., Pottel R. (1990), Ultrasonic absorption and sound velocity of dimethyl sulfoxide/water mixtures in the complete composition range, J. Mol. Liquids, 44, 3-4, 197–209.

Kawaizumi F., Ohno M., Miyagara Y. (1997), Ultrasonic and Volumetric Investigation of Aqueous Solutions of Amides, Bull. Chem. Soc. Jap., 50, 9, 2229–2233.

Last W. (2013), The New Direction in cancer Therapy, vol. 20, no 3, Nexus.

Lautscham K., Wente F., W. Schrader, Kaatze U. (2000), High resolution and small volume automatic ultrasonic velocimeter for liquids, Meas. Sci. Technol., 11, 10, 1432–1439.

Liu L., Guo Q-X. (2002), The Driving Forces in the Inclusion Complexation of Cyclodextrins, J. Inclusion Phenomena and Macrocyclic Chemistry, 42, 1-2,


Miecznik P., Kaczmarek M. (2007), Ultrasonic investigations of inclusion

complexation of α-cyclodextrin by iodide ions in pseudo-binary aqueous system, Journal of Molecular Liquids, 133, 1-3, 120–124.

Nascimento C.S., Dos Santos H.F., De Almeida W.B. (2004), Theoretical study of the formation of the α-cyclodextrin hexahydrate, Chem. Phys. Letters, 397, 4-6, 422–428.

Reijenga J., Ingelse B., Everaerts F. (1997), Thermodynamics of chiral selectivity in capillary electrophoresis: separation of ibuprofen enantiomers with β-cyclodextrin, J. Chromatogr. A, 792, 1-2, 371–378.

Sikorska A., Linde B.B. (2008), Manifestation of hydration effects in dioxane-water solutions by concentration-depend changes of thermal and elastic properties, Chemical Physics, 354, 1, 148–154.

Szejtli J. (1992), The properties and potential uses of cyclodextrin derivatives, Journal of Inclusion Phenomena and Molecular Recognition of Chemistry, 14, 1, 25–36.

Szejtli J. (1998), Introduction and General Overview of Cyclodextrin Chemistry, Chem. Rev., 98, 5, 1743–1754.

Wang C.C., Lin S.-Y., Lai Y.-H., Liu Y.-J., Hsu Y.-L., Chen J.J.W. (2012), Dimethyl Sulfoxide Promotes the Multiple Functions of the Tumor Suppressor HLJ1 through Activator Protein-1 Activation in NSCLC Cells, PLoS ONE, 7, 4.

Żwirbla W., Sikorska A., Linde B.B. (2005), Ultrasonic investigations of water mixtures with poly-ethylene glycols 200, 400 and ethylene glycol, Journal of Molecular Structure, 743, 1, 49–52.

DOI: 10.1515/aoa-2015-0056